Hi Chris Morrow,
1. Check whether compilation debug is set to false in Sitefinity web.config file
2. Create a sample master page - without any controls on it, css, js. Then create Sitefinity page and associate it with this template (master page). Then access the page and see the response. This will help you to narrow the problem - whether it comes from a page content or it comes from somewhere else.
3. What kind of optimizations you have used?
the Telerik team