Hello Sam Eads,
Thank you for your interest in our CMS.
Let me guide you through the steps of configuring Sitefinity to use MySQL database.
1) Create a new user in MySQL Administrator (otherwise you will have to use root credentials).
2) Create a new schema in MySQL Administrator.
3) Assign privileges to the new user you have created for the new database.
4) Run Sitefinity Project Manager, choose to create a new website. At the point for choosing the DB choose MySQL, enter the server address, user name, password and the schema name.
Please refer to attached images for guidance.
the Telerik team