You can do this in Sitefinity 5.0 overriding BuildHttpHandler of PageRouteHandler and after the page set this.Page.Title = "your title";. Then you need to register the custom handler through ObjectFactory class using RegisterType from IUnityContainer.
Another option is overriding SetPageDirectives method of SitefinityPageResolver class and setting the title there.
this.AddPageDirectiveValue(pageAttribs, "Title", "my title");
Then you should register your custom class again through ObjectFactory.
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