You can just use the Sitefinity Project Manager to upgrade your project. If you have side projects, be sure they are upgraded to. Better point them to the \bin directory of your Sitefinity project.
I always run through my solution to find the old version number and replace it with the new one (5.4.4010.0) because sometimes UserControls or Modules have hard-coded version numbers, but you can update them easily.
So, no big deal with this hotfix.