Hi Andreas Kaech,
First, thank you for your interest in our CMS.
Generally, everything is possible. Now seriously - I think this will be easily achieved with Sitefinity. Here are two scenarios that I came up with:
1. One web page per person. You can have one master page (defining the structure of the page) and several themes (defining the look and feel). Every page will represent one business card or a person profile. Additionally, you might use the Pages API to assign a master page, theme and to add controls automatically to the newly created pages.
2. Several web pages for a person. You might use the Group pages approach, and create a page groups for everyone. Everything from above is valid for the page groups as well - you have master pages, themes, controls which can be added programmatically or predefined (via the template option).
Let me know about the details, I will be happy to follow up with additional suggestions or scenarios.
All the best,
the Telerik team