Hi David Belcher,
Thank you for your interest in our CMS and getting in touch with us. We are sorry to hear you are having troubles installing Sitefinity.
Note that Sitefinity is 32-bit, so it is installed into the Program Files (x86) folder.
The error you get is most probably related to the fact that you have not enabled static files in IIS. Here is what you need to do. Please pay special attention to the last step.
1.Open Control Panel and then click Programs and Features.
2.In the left pane, click Turn Windows features on or off. The Windows Features dialog box opens.
3.Select the Internet Information Services checkbox.
4.Expand Web Management Tools, expand IIS 6 Management Compatibility, and then select the IIS Metabase and IIS 6 Configuration Compatibility checkbox.
5.Expand World Wide Web Services, expand Application Development Features, and then select the ASP.NET checkbox. The necessary options will automatically be selected.
6.Expand World Wide Web Services, expand Security and make sure Windows Authentication is selected.
7.Expand World Wide Web Services, expand Common Http Features and make sure Static Content is selected.
You can find more deatils in the Sitefinity User Manual, section Installing Sitefinity under Windows® Vista
Let us know if you need any further assistance.
the Telerik team