Hi Chris Douglass,
We do not have a lot of information about the hosting environment which Mosso provides. The only specific detail that was provided to us is that Mosso is supporting only Integrated Pipeline configuration. We already made our product compatible with it for the latest Sitefinity version 3.2 SP2 HF1616. It was released just two weeks ago, and it is not fully tested yet. It seems that the only problem would be with one of the RadControls (RadUpload), which is not supporting this environment by default.
Hope this helps.
Best wishes,
Nikifor
the Telerik team