Could you give me more information about the Sitefinity edition you are experiencing this problem in?
I'm using a Sitefinity 6.1 freshly built project and just opened the "Go Comment!" label, switched the label text to Read More, the "Save Changes" button was enabled all the time and allowed me to save all as expected. Perhaps this can be reproduced on specific SF edition?
Grisha 'Greg' Karanikolov
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