Hello Steven Lancaster,
If the IP is the same or it comes from some range you could block it by using IIS - IP address and Domain restriction plugin or HttpModule/HttpHander. It is not possible to disable the comments for only one particular post out of the box. You have to map ListPageDetail mode extersnal template and get the currently displayed post using the code below. Then just hide the comments control.
Telerik.Cms.Engine.ContentManager Manager =
// this will return you the id of the currently opened single item
Guid id = (Guid)((Telerik.Web.IUrlRewriteData)Context.Items[Manager.ProvideContentItemKey]).Data;
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