Currently we have not tested official compatibility with AppFabric, however there have been customer experiences where AppFabric has conflicted wiht the proper operation of the WCF RESTful services that operate the Sitefintiy backend. In addition, since we use OpenAccess ORM for our data layer implementation, its data caching can currently be facilitated with the built-in implementation only.
We would like to advise you to schedule the AppPool recycling on intervals where the site is not under heavy load, or utilize Load balancing for handling the high traffic scenraio by multiple servers.
the Telerik team
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