Actually Sitefinity 4.0 is not
tightly integrated with OpenAccess ORM. You can replace the data classes with custom one, but you need to create a custom data provider which you can use in cases when you want to store some data , like Pages, Content in another way. For instance you can create a custom data class that inherits from PageDataProvider. PageDataProvider is abstract class and our OpenAccessPageProvider inherits from it. The situation is the same with Membership and Role providers. It also depends on whether your data layer supports POCO objects - objects that are not tied to a specific context.
All the best,
the Telerik team
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