Thank you for your interest in Sitefinity 4.0.
Sitefinity uses the Provider Model
for data access. To put it in a nutshell for each module (pages, news, blogs, etc), as well as for security (membership, roles, profiles) you have data providers. Each module can work with multiple providers. This means that you will have multi-tennancy support with some additional configuration. I have attached a small video which illustrates how to add connection strings to other databases and set providers to use these connection strings.
Using this approach you can define multiple providers for all modules and page site maps. Also each provider can be secured by its own permissions set, so you can have only certain users having access to certain providers. Then when we have full support for multiple domains you will be able to manage entirely different sites through one instance.
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