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sends all scripts in a single server request rather than separate request for each script needed.
You can turn off script combining in Administration->Settings->Advanced->Pages->ScriptCombining = False.
This is not recommended because the request will slow the performance on visitors`s computers.
I have some tips that may prove useful in reducing the load time.
Enable caching for the whole content of the site. Sitefinity caching is enabled by default so If you have not made changes to this you should be having it.
Make sure the server you are hosting at has enough ram to support the cache and the initial load from visitors. See if you have restriction on the amount of ram you can use.
If you database is at a distant location this will slow the performance.
Set static files expiration in IIS to a different value so that static files are not loaded every time from your project folder in order to be sent to the requesting client. I suppose this is the main slowing factor in your case. If you are using a lot of static images they should be requested from cache.
Also you can check with firebug`s net tab to see if images are slowing the load. Images should be loading 6 at a time(default settings for Firefox) other 6 images are waiting in blocking. Here
is a very good explanation on several topics why blocking occurs. The blocking appears to be caused by simultaneous loading of many items and the browser allows only a certain ( 6 for Firefox) at a time. Observing other websites it appears to be a common scenario when many resources have to be loaded
to prevent it from slowing the performance.
As performance gets better when the site gets visited and the corresponding loads are lower it may be a good option to write a crawler that will visit your site at some time interval in order to prevent the first user performance hit. Here
is a sample tutorial + complete code of a web crawler.
You can also refer to this documentation
on optimizing performance.
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